Neurobiology in the Geller Lab  
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Structure/Function Relationships of Glycosaminoglycan Chains

GAG Chain Receptors

Intracellular Signaling Pathways

Astrocyte Extracellular Matrix

Biophysics of Growth Cones

Tissue Engineering

Lab Protocols

Laboratory of Developmental Neurobiology Division of Intramural Research, NHLBI
Bethesda, MD 20892-1754

Research in the Laboratory of Developmental Neurobiology, headed by Dr. Herbert Geller, is focused on understanding how extracellular signals provide guidance cues to axons.  Our primary focus is on signals derived from the extracellular matrix, espeically proteoglycans, as well as responses of growing neurons to biophysical properties of their environment, such as substrate stiffness.  Our overall goal is to improve recovery of function following brain or spinal cord injury.  This involves use of all methods of modern biology, including light and electron microscopy, including multi-photon and superresolution microscopy, cell biology, including proteomics, constrol of gene expression using CRISPR/Cas systems, and animal models.  

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