Neurobiology in the Geller Lab
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Recent Publications

Petrova, V., Pearson, C. S., Tribble, J. R., Solano, A. G., Reid, E., Williams, P. A., Geller, H. M., Eva, R., Fawcett, J. W. Protrudin functions as a scaffold in the endoplasmic reticulum to support axon regeneration in the adult central nervous system, Nature Comm., in press. [bioRxiv]

Higashi, S. L, Yagyu, K., Nagase, H., Pearson, C. S., Geller, H. M., Katagiri, Y. Ultra-high-speed western blot with the aid of immunoreaction enhancing technology, JOVE, in production.

Mencio, C. P., Hussein, R. K., Yu, P., Geller, H. M., Role of chondroitin sulfate proteoglycans in neural development, J. Hisotchem. Cytochem., in press.

Nagase, H., Higashi, S., Iweka, C. A., Pearson, C. S., Hirata, Y., Geller, H. M., Katagiri, Y. Reliable and sensitive detection of glycosaminoglycan chains with immunoblots, Glycobiology, 2020 Jul 2:cwaa060. doi: 10.1093/glycob/cwaa060.  

Hussein, R. K., Mencio, C. P., Katagiri, Y., Brake, A. M., Geller, H. M., Role of chondroitin sulfation following spinal cord injury, Frontiers in Cell. Neurosci., 2020 Jul 1;168(1):15-22. doi: 10.1093/jb/mvaa016.

Tilve, S., Iweka, C. A., Bao, J., Hawken, N., Mencio, C. P., Geller, H. M. Phospholipid Phosphatase Related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity, Exptl. Cell Res., 2020 Feb 13:111911. doi: 10.1016/j.yexcr.2020.111911. [link]

Higashi, S., Yagyu, K., Nagase, H., Pearson, C. S., Geller, H. M., Katagiri, Y., Old but not obsolete: an enhanced high speed immunoblot, J Biochem. 2020 Feb 6. doi: 10.1093/jb/mvaa016. [link]

Nagase, H., Katagiri, Y., Oh-hashi, K., Geller, H. M., Hirata, Y. Reduced sulfation enhanced oxytosis and ferroptosis in mouse hippocampal HT22 cells, Biomolecules, 10(1). pii: E92, 2020. [Open Access]

Pearson, C. S., Solano, A. G., Tilve, S., Mencio, C. P., Martin, K. R. and Geller, H. M. Spatiotemporal dOld but not obsolete: an enhanced high speed immunoblotistribution of chondroitin sulfate proteoglycans after optic nerve injury in rodents, Exptl. Eye Res.,190:107859, 2020. doi: https://doi.org/10.1016/j.exer.2019.107859 [link]

Singh, K., Han, K., Tilve, S., Wu, K., Geller, H. M., Sack, M. Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation, Glia, 66:2427-2437, 2018. [abstract]

Katagiri, Y., Morgan, A. A., Yu, P., Bangayan, N. J., Junka, R., Geller, H. M., Identification of novel binding sites for heparin in RPTPσ: Implications for proteoglycan signaling, J. Biol. Chem., 293:11639-11647, 2018. [abstract]

Pearson, C. S., Mencio, C. P., Barber, A. C., Martin, K. R. and Geller, H. M. Identification of a critical sulfation in chondroitin that inhibits axonal regeneration, eLife, 2018;7:e37139. [link]

Jin, J., Tilve, S., Huang, Z., Geller, H. M., Yu, P. The effect of CSPGs on neuronal cell adhesion, spreading and neurite growth in culture, Neural Regen. Res., 13:289-297, 2018. [abstract]  

George, N. and Geller, H. M. Extracellular matrix and traumatic brain injury, J. Neurosci. Res., 96:573-588, 2018.[abstract]

Yu, P., Pearson, C. S., Geller, H. M. Flexible roles for proteoglycan sulfation and receptor signaling, Trends Neurosci., 41:47-61, 2018. [abstract]

Yi, M., Wei, T., Wang, Y., Liu, Q.,  Yu, P., Lu, Q., Chen, G., Gao, X., Geller, H. M., Chen, H. and Yu, Z.  The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke,  J. Neuroinflamm., 14:203, 2017 [abstract]

Shumakovich, M. A., Mencio, C. P., Siglin J. S., Moriarty, R.A., Geller, H. M. and Stroka, K. M. Astrocytes from the brain microenvironment alter migration and morphology of metastatic breast cancer cells, FASEB J.,  31:5049-5067, 2017. [abstract]

Yi, M., Yu, P., Lu, Q., Geller, H. M. Yu, Z., and Chen, H. KCa3.1 constitutes a pharmacological target for astrogliosis associated with Alzheimer's Disease, Mol. Cell. Neurosci., 76:21-32, 2016.[abstract]

Janecke, A. R., Li, B., Boehm, M., Krabichler, B., Rohrbach, M., Müller, T., Fuchs, I., Golas, G., Katagiri, Y. Ziegler, S. G., Gahl, W. A., Wilnai, Y., Zoppi, N., Geller, H. M., Giunta, C., Slavotinek, A., Steinmann, B. The phenotype of the musculocontractural type of Ehlers-Danlos syndrome due to CHST14 mutations, Amer. J. Med. Gen. Part A, 170:103-15, 2016.  [abstract]

Polackwich, J., Koch, D., McAllister, R., Urbach, J. S., Geller, H. M. Traction force and tension fluctuations in growing axons, Front. Cell. Neurosci., 9:417. doi: 10.3389/fncel.2015.00417, 2015 [abstract].

Yu, P., Agbaegbu, C., Malide, D., Wu, X., Katagiri, Y., Hammer, J. A. and Geller, H. M. Cooperative interactions of LPPR family members in membrane localization and alteration of cellular morphology, J. Cell Sci., 128:3210-22, 2015. [abstract]

Smirnov, M. S., Cabral, K. A., Geller, H. M. and Urbach, J. S. The effects of confinement on neuronal growth cone morphology and velocity, Biomaterials, 35:6750-7, 2014. [abstract]

Susarla, B., Villapol, S., Yi, J. H., Geller, H. M., Symes, A. J. Temporal patterns of cortical proliferation of glial cell populations after traumatic brain injury in mice, ASN Neuro, 6:159-70 2014. [abstract]

Yu, Z.-H., Yu, P., Chen, H.-Z., Geller, H. M. Targeted inhibition of KCa3.1 attenuates TGF-β-induced reactive astrogliosis through the Smad2/3 signaling pathway, J. Neurochem., 130:41-9, 2014. [abstract]

Yi, J. H., Katagiri, Y., Yu, P., Lourie, J., Bangayan, N. J., Symes, A. J. and Geller, H. M. Receptor protein tyrosine phosphatase σ binds to neurons in the adult mouse brain, Exptl. Neurol.,255:12-18, 2014. [abstract]

Mora, K. E., Cohen, J. D., Yu, P., Geller, H. M. and Morgan, N. Y., Microfluidic deposition of chondroitin sulfate proteoglycan surface gradients for neural cell culture. Microsystems for Measurement and Instrumentation (MAMNA), 20-23, 2013.

Geller, H. M. Above the Genome (Editorial). Int. J. Dev. Neurosci.31:351–352, 2013. [abstract]

Yu, P., Pisitkun, T., Wang, G., Wang, R., Katagiri, Y., Gucek, M., Knepper, M. A. and Geller, H. M. Global analysis of neuronal phosphoproteome regulation by chondroitin sulfate proteoglycans, PLoS One, 8:e59285, 2013.[abstract]

Zhou, Z., Yu, P., Geller, H. M. and Ober, C. Biomimetic polymer brushes containing tethered acetylcholine analogs for protein and hippocampal neuronal cell patterning, Biomacromolecules,14:529-37, 2013. [abstract]

Yi, J. H., Katagiri, Y., Susarla, B., Figge, D., Symes, A. J. and Geller, H. M. Detection of sulfated chondroitin glycosaminoglycans following controlled cortical impact injury in mice, J. Comp. Neurol., 520:3295-313, 2012. [abstract]

Dickendesher, T. L., Baldwin, K. T., Mironova, Y. A., Koriyama, Y., Raiker, S. J., Askew, K. L., Geoffroy, C. G., Zheng, B., Liepmann, C. D., Katagiri, Y., Benowitz, L. I., Geller, H. M., Giger, R. J. NgR1 and NgR3 are inhibitory receptors for chondroitin sulfate proteoglycans, Nature Neurosci., 15:703-12, 2012. [abstract]

Yu, P., Santiago, L. Y., Wang, H., Katagiri, Y. and Geller, H. M. Myosin II activity regulates neurite outgrowth and guidance in response to chondroitin sulfate proteoglycans., J. Neurochem., 120:1117-1128, 2012. [abstract]

Koch, D., Rosoff, W. J., Jian, J., Geller, H. M. and Urbach, J. S. Strength in the periphery: Growth cone biomechanics and substrate rigidity response in peripheral and central nervous system neurons, Biophys. J., 102:452-460, 2012. [abstract]

Zhou, Z., Yu, P., Geller, H. M. and Ober, C. The role of hydrogels with tethered acetylcholine functionality on the adhesion and viability of hippocampus neurons and glial cells. Biomaterials, 33:2473-2481, 2012. [abstract]

Yu, P., Wang, H., Katagiri, Y. and Geller, H. M. An in vitro model of reactive astrogliosis and its effect on neuronal growth. In: Astrocytes, Methods and Protocols, R. Milner, ed., Humana Press, Methods in Molecular Biology, 814:327-40, 2012. [abstract]

Susarla, B. T. S., Laing, E. D., Yu, P., Katagiri, Y., Geller, H. M. and Symes, A. J. SMAD proteins differentially regulate TGF-β mediated induction of chondroitin sulfate proteoglycans, J. Neurochem., 119:868-78, 2011. [abstract]