Neurobiology in the Geller Lab  
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Structure/Function Relationships of Glycosaminoglycan Chains

GAG Chain Receptors

Intracellular Signaling Pathways

Astrocyte Extracellular Matrix

Biophysics of Growth Cones

Tissue Engineering

Lab Protocols

Laboratory of Developmental Neurobiology
Division of Intramural Research, NHLBI
Bethesda, MD 20892-1754

Geller Lab Research > Tissue Engineering

The glial scar is a major impediment to regrowing axons.  Our goal is to develop tissue engineering methods to encourage neurons to grow through the scar.  These methods include understanding how neurons grow in confinement as well as developing substrates that promote axonal growth.  Further research will use new methods of substrate fabrication as well as new biomatierials. 

• Smirnov, M. S., Cabral, K. A., Geller, H. M. and Urbach, J. S. The effects of confinement on neuronal growth cone morphology and velocity, Biomaterials, 35:6750-7, 2014.

• Mora, K. E., Cohen, J. D., Yu, P., Geller, H. M. and Morgan, N. Y., Microfluidic deposition of chondroitin sulfate proteoglycan surface gradients for neural cell culture. Microsystems for Measurement and Instrumentation (MAMNA), 20-23, 2013.

• Zhou, Z., Yu, P., Geller, H. M. and Ober, C. Biomimetic polymer brushes containing tethered acetylcholine analogs for protein and hippocampal neuronal cell patterning, Biomacromolecules, 14:529-37, 2013.

• Zhou, Z., Yu, P., Geller, H. M. and Ober, C. The role of hydrogels with tethered acetylcholine functionality on the adhesion and viability of hippocampus neurons and glial cells. Biomaterials, 33:2473-2481, 2012.

• Krsko, P., McCann, T. E., Thach, T.-T., Laabs, T.L., Geller, H. M. and Libera, M. Length-scale mediated adhesion and directed growth of neural cells by surface-patterned poly(ethylene glycol) hydrogels, Biomaterials, 30:721-729, 2009.

• Geller, H. M. and Fawcett, J. W. Building a bridge: Engineering spinal cord repair, Exptl. Neurol, 174:125-36, 2002.